Sentence examples for by modifying the sequence from inspiring English sources
Using analytical ultracentrifugation and NMR methods, we show here that a membrane-soluble peptide, MS1, designed by modifying the sequence of the water-soluble coiled-coil GCN4-P1, exhibits a reversible monomer-dimer-trimer association in detergent micelles with a greater degree of cooperativity in C14-betaine than in dodecyl phosphocholine detergents.
This model could be tested experimentally in vivo by modifying the sequence lengths of reporters and studying the effects on chromosome structure using chromosome-structure capturing assays [24].
There is room for improvement by modifying the sequence of miRNAs or finding other sequences common to mRNAs or proteins of interest.
In general, the MESA platform enables design-based receptor engineering because it is possible to tune specific biophysical parameters by modifying the sequence of specific receptor domains.
The new A3 copies could explore the sequence space that expands the family of substrates for the action of deaminases, typically by modifying the sequence context of the C- > U edition.
Much has been learned about both the activation and inhibition of the nucleic acid TLRs through relatively straightforward experiments by modifying the sequence and structural motifs in synthetic oligonucleotides.
This positional information could be useful in detecting CNEs over large evolutionary distances, under the assumption that evolution sometimes proceeds by modifying the sequences of existing cis-regulatory CNEs without significantly changing their relative position [ 31].
Although the bulk of this paper focuses on heterogeneity estimation and improving SV predictions by refining soft-clipping at candidate breakpoints, the other main purpose of SHEAR is to generate personal genomic sequences by modifying the reference sequence using the most common set of predicted variants, or the set of variants chosen by the user.
It also prevents the binding of Sp1 transcription factor to its cognate site in DNA by modifying the CG sequences [ 19].
Alteration of the three-way junction conformation (with unpaired bases) can be induced by various factors, including modifying the sequence around the junction, macromolecular crowding, hydration state, protein interaction, and small molecule interaction.
