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We previously showed that activation of the cAMP-PKA signal potentiates SF-1 transactivation by modifying the interactions between SF-1 and its cofactors, and PKA-induced activation of ArPII requires SF-1 (Fan et al. 2004).
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The effect of foundation settlement on the bridge vehicle interaction (BVI) is investigated by modifying the interaction forces due to the deformed shape of deck.
The performance of this computationally expensive problem is improved by modifying the interaction potential due to nearby particle moves, instead of fully recalculating it.
At this frequency and regardless of pressure, the flame motion is driven by flame vortex roll-up, suggesting that pressure affects the FTF by modifying the interaction of the flame with the vortex detached from the injector rim during a forcing period.
This R55K K225R double mutation may either severely disrupt the function of the active site by modifying the interaction between the substrates, or cause protein misfolding.
The PPARG Pro12Ala amino acid substitution abolishes the alcohol-specific regulation of PPARG presumably by modifying the interaction with the cofactor PGC-1α.
The effect of INH is captured by modifying the interaction of its known target, NADH-dependent enoyl-[acyl-carrier-protein] reductase, inhA (Rv1484) [ 45].
Methylation does not interfere only in transcription factor binding activity, but also modulates chromatin structure by modifying the interaction between core histones and DNA.
Testosterone may interfere with the effects of cholinesterase inhibitors by decreasing the amount of drug that reaches the brain or by modifying the interaction of the cholinesterase inhibitor with cholinesterase [ 103, 104].
48– 50 For rs4532, located in the 5′ untranslated region of DRD1 gene, the variant modulates the expression and stability of mRNA and influences DRD1 gene expression by modifying the interaction between DNA binding domain and the regulatory elements.
Taken together, our findings indicate that VvMYB5bL is still able to bind DNA but the structural consequences linked to the mutation affect the capacity of the protein to activate the transcription of some flavonoid genes by modifying the interaction with its co-partner(s).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com