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For the discrete risk model, Tan and Yang [16] propose a randomized dividend strategy by modifying the compound binomial model.
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Herein, by modifying the hit compound 7k from an in-house database, 48 derivatives were synthesized for the assay of their Kv1.5 inhibitory effects by whole cell patch clamp technique.
The estimated FDRs suggest that the quality of search results can be improved not only by performing more accurate mass analysis but also by modifying the properties of the compound database.
The estimated FDRs indicated that the quality of search results can be improved not only by performing more accurate mass analysis but also by modifying the properties of the compound database (Table 1).
In our preliminary effort, we also demonstrated that the potency of catechol compound as Stat3 SH2 inhibitors could be improved by modifying the non-catechol part of the compound structure.
We improve the reference prediction (a) by modifying the predicted probability of a single compound at different positions in the ranking: in (b d), a single active compound is predicted with higher probability and shifted 4 positions upwards in the ranking.
This part of the study aims to clarify whether the distribution of main ash forming elements from biosolids can be changed by modifying the fuel matrix, the crystalline compounds of which can be identified in the raw materials and what role the total composition may play for which compounds are formed during combustion.
By modifying the chemical structure of anti-orthopoxvirus compound ST-246, we designed and synthesized a series of tricyclononene carboxamide derivatives and tested their anti-HIV-1 activity and cytotoxicity.
Using QSAR model no 1 (best model), a number of s-triazine compounds were designed by modifying the attached side chains to the carbon atoms of the triazine ring of the parent compound (Table 1).
Some brewers get around that problem by extracting the bitter compounds from hops, a process analogous to producing vanilla extract from vanilla, and modifying the compounds so that they are no longer susceptible to light.
Both RIB1 (YBL033C) and RIB4 (YOL143C) are fixed not by modifying the iMM904 model but by adding missing compounds to the in silico YP medium description.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com