Sentence examples for by modifying the binding from inspiring English sources

We hypothesized that CpG methylation status is able to influence the expression of FABP3 by modifying the binding affinity of the region for specific transcription factors.

Mutations in the D-loop regulatory region might alter the rate of DNA replication by modifying the binding affinity of significant trans-activating factors.

In addition, H3K9 demethylation can participate in IL-1β-induced mPGES-1 expression by modifying the binding of chromatin factors and/or regulators.

Nevertheless, more recent data suggest a direct functional effect of the -308 SNP by modifying the binding of transcription factors [ 24].

These SNPs have wide range of frequency (∼0.001 0.48) in the population and could influence the rate of gene expression by modifying the binding affinity of transcription factors.

Because ax2005 does not improve kinase activity detectably in vitro, ax2005 may modulate MBK-2 activity indirectly by modifying the binding of a regulator.

Introducing point mutations in the genomic loci of RTKs, such as TrkC, TrkB, Met, Pdgfr or Ret, by selectively modifying the binding sites through which they recruit cytoplasmic effectors, has been instrumental in distinguishing the respective contribution of signalling adaptors, such as PLCγ, Shc, Grb2, PI3K and Src, in mediating qualitatively distinct cellular responses in vivo [ 7– 12].

Expressionally modulating these four genes by modifying the ribosome binding site further promoted cellular performance, achieving ABE solvent titer and productivity as high as 21.9 g/L and 0.30 g/L/h, respectively, in biotin-free medium; these values exceeded those of the wild-type strain by over 30%.

These results suggest that TAM67 may inhibit AP-1 transcriptional activity by modifying the DNA binding of AP-1 components.

Mutations can promote formation of Alu exons either by modifying the competitive binding of U2AF65 and hnRNP C, or by increasing the strength of splice sites within Alu elements, or act on additional enhancer or silencer elements [ 2].

48– 50 For rs4532, located in the 5′ untranslated region of DRD1 gene, the variant modulates the expression and stability of mRNA and influences DRD1 gene expression by modifying the interaction between DNA binding domain and the regulatory elements.