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To study this phenomenon, we have either examined cell lines with differential expression of sphingolipids (such as GM3), or altered membrane organization by modifying levels of cholesterol, ceramides, or glycosphingolipids.
Yet another risk factor that was thought to modify breast cancer risk is intake of dietary fat, theoretically by modifying levels of endogenous estrogen.
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Queitsch et al [ 38] produced transgenic A. thaliana plants by modifying level of AtClpB-cyt/HSP100 protein.
This adaptability can be achieved in different ways, such as by modifying levels and/or temporal patterns of hormonal synthesis and secretion, but it has also been proposed that a population of adult progenitor/stem cells is involved.
This would predict that lengthy exposure to the drug will influence translation by modifying the levels of initiation and elongation factors.
Al has also been shown to impact root growth by modifying the levels of phytohormones such as auxin [ 89] and ethylene [ 8].
In addition, by modifying the levels of the receptors, we created two additional models: mIL-6R+/sIL-6R−, obyained by specifically inhibiting IL-6TS in LNCaP and Du145 cells by sgp130; and mIL-6R−/sIL-6R+, in which the sIL-6R has been added to the cells after knockdown of both soluble and membrane IL-6Rs.
Activity altering polymorphisms in FasR (−1377G > A and -670A > G), FasL (−844 T > C) and CASP8 (−652 6 N ins/del) genes have been shown to alter the mechanism of apoptosis by modifying the level of expression of their correspondent proteins.
Thus, the activity of MRFs can be regulated by modifying the level of the MRF or one of its partners.
Users can come up with their own pickup lines and personalize the app in other ways, like by modifying their level of swiping "pickiness"—but I chose to go with the wisdom of default settings.
Interestingly, this effect can be also obtained in our case by modifying the level of depression (note that in the present study we use a logarithmic scale for the frequency domain, which indicates that the second resonance peak is in fact a very broad peak).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com