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Second, experimentally-derived mechanistic models can be tested by modelling the effects of past environmental change and comparing the outcomes to known changes in range distribution.
By modelling the effects of life events in young adult twins, Spatola et al. [19] recently found that adversities that take place within the childhood-adolescence window of risk moderate the genetic variance for CO2 sensitivity, as assessed by a CO2 challenge provocation test.
In this study we have investigated the role of transposition bursts on the survival of ISs in a bacterial population by modelling the effects of IS movements on the fitness of host genomes.
By modelling the effects of introduction on maladaptive, neutral and adaptive variation, practical guidance was obtained on the optimal number of immigrants – that is, the level of immigration that gave the greatest chance of relieving inbreeding depression with the lowest risk of diluting adaptive variation.
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The presented indicator may be used to explore the dynamics of biodiversity following policy interventions, using the biodiversity map or by modelling the effect of policies on the environmental pressures that form the basis of the indicator.
This issue was analyzed by modelling the effect of mean tree diameter and stand basal area on the increment in NPV.
By modelling the effect on receptor binding of each mutation at all thirteen sites that differed between A/Panama/2007/99 and A/Fujian/411/02 viruses (Fig. S3 and Fig. S4), we found that the mutations at residues 222 and 225 played the most important role in mediating receptor binding alterations in the Fujian-like viruses (The detailed analysis is given in the legends of Fig. S3).
Violations of the proportional hazards assumption were handled by stratifying on the violating covariate or by modelling the effect as time dependent.
The response might be clearer by modelling the effect of D*w, with w some more general function of Time-Since-Exposure.
The contribution of certain vascular innovations in augmenting immune functionality of an AIS can be tested by modelling the effect of different vascular parameters on AIS efficacy.
Burden tests of association have been developed by modelling the effect of accumulations of minor alleles at rare variants, referred to as the 'mutational load', within some functional unit or genomic region.
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