Sentence examples for by mitochondrial dysfunction and from inspiring English sources

We concluded that DON-induced apoptosis was caused by mitochondrial dysfunction and subsequent release of cytochrome c into the cytoplasm and successive activation of caspases, and this was likely regulated by Bcl-2 family proteins.

Therefore, radical injury in CS was not worsened by iNOS overexpression, but by mitochondrial dysfunction and decreased SOD activity.

Fus1 KO mice are characterized by mitochondrial dysfunction and elevated oxidative stress.

Overexpression strains were characterized by mitochondrial dysfunction and accelerated aging as the result of the induction of apoptosis.

As this process is mainly preceded by mitochondrial dysfunction and activation of caspases, we next analyzed whether ER-Ca2+ release through RyRs contributes to this apoptotic cascade.

Autophagy and apoptosis have been shown to be regulated by numerous aspects of glucose metabolism and can also be activated by mitochondrial dysfunction and oxidative stress [ 37].

Retrograde signaling pathways result in the activation of nuclear transcription factors, and one relevant example might be the transcriptional coactivator PGC1α (peroxisome proliferator-activated receptor γ, coactivator 1 α), which is a master regulator of mitochondrial biogenesis in mammals and is induced by mitochondrial dysfunction (Butow and Avadhani, 2004; Chae et al., 2013).

These structural changes are accompanied by mitochondrial dysfunction, oxidative stress and increased cell death, which strongly affect the secretory function of the CP.

The recent awareness that many signaling pathways converge to a common bottom line, the metabolic rewiring, characterized by mitochondrial dysfunction, enhanced glycolysis and stimulated glutamine utilization through a reductive carboxylation reaction, offers the possibility of developing a new strategy for anticancer drug discovery.

Upon αB-crystallin R120G overexpression, amyloidogenic oligomers were detected in the heart, suggesting that toxic oligomers generated by this mutation may affect apoptotic pathways by inducing mitochondrial dysfunction and disrupting the cytoskeletal network [8], [12].

Patient's IgG4 caused a drop in cell pH followed by mitochondrial dysfunction, excessive ROS production and cytoskeletal reorganization in cultured podocytes.