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This review focuses on some recent advances in the identification of vaccine candidates by mining the genomic sequences of pathogenic bacteria.
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We compared the patterns of diversification between TE families, by mining the genome with the de novo consensus sequences, using BLAT [62] for the rapid identification of well conserved genomic copies.
To increase marker density in the QTL candidate region, microsatellite markers were selected from the SWR453- SW1987 interval on the USDA-MARC SSC5 linkage map [ 8] or by mining genomic sequence data of the QTL region (Sscrofa 9.2) using the SSRHunter program [ 9].
The target genes comprising candidate gut sucrase, aquaporin and sugar transporter genes were identified by mining insect genomic and transcriptomic datasets for genes orthologous to empirically-tested osmoregulatory genes of the pea aphid Acyrthosiphon pisum.
A set of 97 SSR markers were also developed by mining 9,517 genomic survey sequences of Arachis.
Therefore, it can deepen our understanding of the origin and progression of disease, by mining association between clinical data and genomic data from massive available biomedical big data, which promote the bidirectional translation between clinical research and basic research, and ultimately achieve the purpose of promoting the development of personalized medicine.
In this work, we introduce LD-Spline, an efficient database procedure for establishing genomic regions that a SNP potentially represents by mining linkage disequilibrium statistics available from the International Hapmap Project.
Theoretical results are illustrated using several empirical examples constructed by mining sequence databases, genomic libraries such as ESTs and BACs, and complete genome sequences.
Developing a plant intronless genes database could greatly aid research by data mining such valuable genomic resources.
The HCG group showed a much higher conversion rate of 61.1%; this rate is comparable to those SNPs mined by genomic re-sequencing in other tree species [ 31, 32].
The intron/exon junctions for exons 1 to 4 and 16 were determined by database mining using genomic Txnrd1 DNA sequences deposited in the Trace Archive of the NCBI.
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