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Bisphosphonates are drugs that share a phosphorus-carbon-phosphorus backbone and decrease risk of fracture by minimizing bone resorption.
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Strategies to minimize bone resorption after autologous grafting are discussed in the literature.
Although in vivo data is very limited, it was found to be successful in preventing socket from collapse by minimizing the horizontal bone resorption [ 70– 72].
Several clinical procedures have been advocated to clinically minimize this bone resorption.
The material is composed of a graded lattice with controlled property distribution that minimizes concurrently bone resorption and interface failure.
Bone mass is dependent on the balance between bone formation by osteoblasts and bone resorption by osteoclasts.
Bone metabolism is a continuous remodelling process involving both bone formation by osteoblasts and bone resorption by osteoclasts.
For bone, our primary interest involved genes controlling bone formation by osteoblasts and bone resorption by osteoclasts.
Subcutaneous administration of leptin attenuates bone loss in ovariectomized (ovx) rats by reducing bone resorption.
Hyperparathyroid bone disease is characterised by subperiosteal bone resorption, sclerotic bone changes and/or terminal tuft reabsorption (Fig. 7) [8].
Therefore, LP may maintain bone strength by reducing bone resorption and increasing bone formation activities [ 95].
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