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In addition, several gene perturbations identified by microarray profiling have also now been confirmed in HGPS fibroblasts [31] [32] [33] [34], but very few have been validated extensively in animal models.
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Another lesson learned from the data shown in Figure 11 was that SMF treatment set in motion a complex sequence of events that rapidly changed over time; consequently, the original goal of analyzing cellular responses by microarray profiling could have led to erroneous conclusions.
At least four genetically distinct breast cancer subtypes have been defined by microarray profiling [ 89], and at least two types of stem cells have been identified within these subtypes - basal progenitors and luminal progenitors [ 90].
Placenta and fetal liver at 15.5 days gestation were analyzed by microarray profiling.
In previous studies, chromosomal alteration analysis by CGH and gene expression profiling by microarray analysis have been investigated in various cancers (Inazawa et al, 2004; Ishkanian et al, 2004).
The gene expressions profiled by microarray technology have been a major strategy to detect mRNA abundance.
miRNAs expression profiles by microarray analysis have shown that the miRNAs most highly expressed in normal cervix were miR-145, miR-26a, miR-99a, let-7a, miR-143, let-7b, let-7c, miR-125b, miR-126, and miR-195, in that order [ 11, 18, 30, 31].
One of the commercial microarrays for microRNA profiling has been developed by Agilent Technologies.
Microarray-based transcriptional profiling has been widely used for identifying genes responsible for preeclampsia.
Chicken embryonic skin microarray profiles, which had been described by Hughes et al., were obtained from Chuong's laboratory [ 21].
In the last decade, comprehensive whole genome expression profiling by microarray technology has extensively defined breast cancer into distinct molecular subtypes that differ in terms of patient outcome and response to systemic treatment.
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