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Most trials in this area are limited by methodological weaknesses including small sample sizes and short supplementation durations, ranging from eight weeks [ 18] to four months [ 19].
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The majority of studies reviewed contained methodological weaknesses including; inappropriate study design, limited sample representativeness, the use of ecological data to evaluate individual behaviour change and failure to adequately control for potentially confounding variables.
Both suffered from major methodological weaknesses including very small sample sizes.
Both had important methodological weaknesses, including inadequate method of randomisation, visual estimation of blood loss for determining outcome measures, and limited sample sizes.
Further limitations to the existing evidence on admission and detention rates in the FEP population are methodological weaknesses including small sample sizes and poorly defined, at times meaningless, ethnic categorisations (often merging highly heterogeneous populations) thereby limiting generalisability.
These inconsistent findings may be due to the use of different measures of exposure and methodological weaknesses including self-reported measure of exposure, small samples (N=94 665) and selection or recall bias (refer to web appendix: Supplementary Table A1).
A further methodological weakness includes an incomplete set of inflammatory markers for all patients undergoing revision.
The reliability of this overview could be greatly influenced by any bias in the review process or by methodological weaknesses in the primary studies included.
The range of MRSA rates may reflect differences in specific national characteristics (countries with known higher MRSA rates), but may also be caused by methodological weaknesses, as seen by the quality of the included studies.
Many animal studies are flawed by methodological weaknesses that compromise study validity and reproducibility.
However, the reliability of these findings is limited by methodological weaknesses of the studies.
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