Sentence examples for by methodological drawbacks in from inspiring English sources

In fact, beneficial effects of bone-acting drugs in OA are increasingly reported, but reliable conclusions regarding their efficacy are hindered by methodological drawbacks in study design [ 10].

There have also been methodological drawbacks in the studies that have examined the volume-effectiveness relationship, and several suggestions for methodological improvements have recently been pointed out [ 11- 13].

16 A review 17 examining trials of LA in a range of orthopaedic diseases was equivocal, but noted methodological drawbacks in the studies included.

However, it should be noted that methodological drawbacks in the design and reporting of PROs have often limited the use of PRO data in approval of drugs [ 7].

The present paper gives a summary of reasons for categorisation and methodological drawbacks of this approach.

A methodological drawback in many of these studies is that HRQoL was no longer evaluated once tumor progression occurs.

Our study is limited by some methodological drawbacks which need to be discussed.

The development of gastric tonometry as a practical clinical technique has been limited by both methodological drawbacks and problems of interpretation.

The methodological drawbacks of studies on diets in CKD are similar to those of dialysis: randomization of peritoneal dialysis versus haemodialysis is considered 'unethical and unpractical'.

Overall, a small number of sites have been identified by available evidence on the human body as suspected targets, especially the bladder, but drawing crucial conclusions regarding causality is hindered by intrinsic questions such as methodological drawbacks, exposure assessment limitations [ 38, 40].

In cancer RCTs methodological drawbacks have often hampered a critical appraisal of results [ 9, 10].