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This may be because all relevant RCTs were limited by methodological defects, including inappropriate sample size, variability of acupuncture and sham protocols, and missing information.
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Feeding problems are frequent in children with DS and may be caused by associated defects, including congenital heart defects, gastrointestinal defects, or endocrine disorders.
This can be caused by defects including elevated DNA damage, weakened cell cycle checkpoints or an aberrant mitotic spindle1.
ToF is a complex malformation characterised by four heart defects, including ventricular septal defect, an overriding aorta, PS and RV hypertrophy.
Furthermore, knocking down zfTPP1 by morpholino antisense oligos led to developmental defects including neural death, heart malformation and caudal defect.
The strongest developmental defects, including lethality, were obtained by overexpressing mblC.
Previous studies and estimates have been hampered by methodological issues including small sample sizes and lack of objective measures.
21 The findings may, however, have been complicated by methodological limitations, including the small numbers included and a study design susceptible to recall bias.
Road defects include cracks and potholes recorded on carriageways, hard shoulders and lay-by surfaces.
These defects include decreased responsiveness to visual novelty and decreased distractibility by competing visual stimuli.
These defects include lattice defects, with possible creation of vacancies, as well as chemical changes induced by the hydrogen sticking to the lattice [7, 8].
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