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IL-1F6 is known as a member of the IL-1 gene family, and its product has been identified as a member of the IL-1 cytokine family, which regulates inflammation by mediating the expression of various cytokines, chemokines, nitric oxide synthases, and MMPs [36].
This is achieved by mediating the expression and/or activity of certain metabolic enzymes and transport systems [ 74, 75] involved in metabolic pathways [ 76- 80].
In addition, overexpression of IFITM1 has been shown to promote head and neck tumor invasion by mediating the expression of matrix metalloproteinases 12 and 13 [ 32].
More recently, investigators have reported that overexpression of IFITM1 promotes head and neck tumor invasion in the early stages of disease progression by mediating the expression of molecules downstream, including matrix metalloproteinases 12 and 13 [ 32].
Akt activity itself downstream of HGF/Met is implicated in tumor angiogenesis by increasing vascular endothelial growth factor secretion, and by mediating the expression of nitric oxide and angiopoietins.
Recent studies have reported that miRNA-205 is frequently deregulated in multiple tumour entities and involved in various crucial pathways, such as cell proliferation, apoptosis and angiogenesis, by mediating the expression of multiple oncogenes (figure 7).
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The E2F family of transcription factors plays a key role in the regulation of cell growth, apoptosis, and oncogenic transformation by mediating the timely expression of genes involved in these processes [ 37].
Hence, the GhmiRnD promoted cotton fiber elongation by mediating the decrease in ACCD expression and diverting more carbon into fiber growth.
By the way, NF-κB mediates the expression of anti-apoptotic and pro-apoptotic proteins.
RACK1 translocated to the nucleus in glioma and neuroblastoma cell lines upon PKA activation by forskolin [ 39] to mediate the expression of a brain-derived neurotrophic factor.
miRNAs regulate genes by mediating gene expression at the post-transcriptional level in plants mainly through mRNA cleavage at certain sites [ 44].
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by substituting the expression
by studying the expression
by increasing the expression
by mediating the reversal
by mediating the phosphorylation
by mediating the activation
by regulating the expression
by mediating the formation
by mediating the adherence
by mediating the elimination
by mediating the recognition
by mediating the leukocyte
by mediating the assembly
by mediating the retrograde
by mediating the endocytosis
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