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PVM measures the likelihood that two proteins interact by measuring interactions between their paralogues.
We used this tool to create a chemical epistasis miniarray profile (ChE-MAP) by measuring interactions between the chemically inhibited Tor2 kinase and a diverse library of deletion mutants.
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The genome-wide chromosome conformation capture (Hi-C) approach can characterize the landscape of 3D genome organization by measuring interaction frequencies between all genomic regions.
The simplified model that is proposed here will have to be improved for instance by measuring how interactions between viral and host proteins are essentials for the virus or yet dispensable for the life of the host.
For example, Pappalardo et al. [28] propose a definition of tie strength by measuring the interaction between two individuals over three different social channels: Facebook, Twitter, and Foursquare.
We confirmed these results by measuring the interaction between the HECT domains and monomeric and dimeric ubiquitin by fluorescence polarization and surface plasmon resonance (SPR) assay (Fig 2C; supplementary Fig S1D F online).
Chemical modification could be followed quantitatively by measuring the interaction force between the scanning tip and the mica surface.
Efficacy of the proposed methods has been proved by measuring the interaction forces between the tool and the last handled by a robot during different technological operations (roughing, polishing etc) typical of the shoe fabrication cycle.
Using this measure, interactions between proteins with many different interacting partners (i.e., frequent interactors) have a high probability of occurring by random chance, indicating either promiscuous or strongly context-dependent interactions.
The mechanism of non-productive binding is further studied by measuring non-specific interactions between the immobilized cellulase system and AFM particle tips functionalized with moiety groups.
This detector configuration provides the two-dimensional position information and the depth of interaction by measuring signal ratios between the first and the second photo-strip sensors.
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