In our study, we used physiologically relevant doses of ascorbate that were verified by measuring a range of tissue concentrations and comparing to wild-type levels.
In particular, we have developed a portable optical instrument using visible-near-infrared light to evaluate the local microcirculation of periodontal tissues by measuring tissue hemoglobin concentrations and oxygen saturation in a non-invasive and real-time manner [ 13, 16, 17, 23].
Oxidative injury from VILI was determined by measuring the tissue concentration of malondialdehyde (MDA), a marker of lipid peroxidation, by means of the MDA-586 kit (OxisResearch; Percipio Biosciences, Inc., Foster City, CA, USA) in accordance with the manufacturer's instructions.
To simulate a heart attack, they stopped the flow of saline; the device mapped the loss of oxygen by measuring the tissue's pH level.
In contrast, magnetic resonance imaging (MRI) overcomes this limitation of MRS by measuring adipose tissue across multiple bones (9, 16).
By measuring these tissue Doppler velocities in different regions within the myocardium, regional myocardial function can be assessed.
To date, three published case control studies have examined the association between percent PMD and risk of breast cancer by measuring breast tissue volumes.
The efficacy of ALA PDT was evaluated by measuring the tissue pO2 (Blumenroder et al, 1997; Hartmann et al, 1997; Curnow et al, 2000; Niedre et al, 2002) since tissue pO2 correlates with a functional microcirculation (Vaupel, 1994).
Near-infrared spectroscopy (NIRS) has been used to quantify sepsis-induced metabolic alterations by measuring variations of tissue oxygen saturation (StO2) during a vascular occlusion test (VOT).
Paladino and colleagues [ 19] recently assessed the additional use of metabolic parameters (for example, BD as a sensitive indicator of blood loss by measuring tissue perfusion) to traditional triage vital signs to distinguish major from minor trauma.
