Functional dependence of these insertion mutants on Hsp90 was further supported by the marked sensitivity of total and phospho-ErbB2 to slightly longer exposure (4 h) to 17-AAG.
The structure factor analysis also demonstrates a marked sensitivity of the respective diffraction spot intensities to a slight change in both side group position and side group bulkiness.
However, the role of vimentin in WFA-induced toxicity is strongly supported and is reflected in the marked sensitivity of vimentin-expressing cells to the compound when compared to other cancer cells (as evidenced by IC50 values in the nanomolar vs. micromolar range, respectively).
Despite the marked sensitivity of the medulloblastomas to the epipodophyllotoxins, three early passage cultures were much more resistant to these drugs than the average for the group.
Patients with NBS are characterised by stunted growth, microcephaly, marked sensitivity to ionising radiation, chromosome translocations, and increased incidence of leukaemia and lymphoma.
An elucidation of virus specificity, particularly the marked sensitivity shared by relatively dissimilar viruses like WNV and DCV, will require a better understanding of the underlying mechanism, or mechanisms, by which Wolbachia infection increases viral resistance.
Overall, a clearance route has been revealed in the early post-translational processing of proinsulin that is characterized by marked ATP/redox sensitivity (yin) counterbalanced by a maturation route that is partially dependent upon ATP (yang).
As regards E. coli, after three hours, a marked sensitivity to treatment has been observed, regardless of the amount of the ozonated oil.
Of the cell lines examined, the response of UMCL01-101 most closely resembled that of LCL8664 in that the marked sensitivity to TGF-β1-mediated growth inhibition was rescued in part by treatment with IL-6.
Thus, expression of mre11-H59A conferesistantstont to ETP and CPT, despite marked sensitivity to HU and IR; and expression of mre11-H125N strain conferred resistant to ETP, despite sensitivity to CPT, HU and IR.
