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The treatment with siMEF2C was accompanied by marked reduction of MEF2C transcripts, but not of those from MEF2A, MEF2B or MEF2D (Figure 2C-F), after normalization to GAPDH.
Consistent with this, the reduced levels of nucleolin mRNA in response to inhibition of RNA transcription is accompanied by marked reduction of surface and cytoplasmic but not nuclear nucleolin.
As for the nucleolin protein expression, the reduced levels of nucleolin mRNA in actinomycin D treated cells is accompanied by marked reduction of surface and cytoplasmic but not nuclear nucleolin, thus indicating that the expression of surface/cytoplasmic nucleolin is dependent on the constant induction of nucleolin mRNA.
This was indicated by marked reduction of absorbance in NF-κB level in groups IV-IX in comparison to group II (0.132 ± 0.003).
The analysis of adult Tg mice revealed that skeletal muscles are characterized by marked reduction of fiber CSA and by mitochondrial alterations, namely, increase in SDH and total cytochrome c levels.
Administration of FZHY and NAC reduced collagen accumulation as evidence by marked reduction of Hyp content.
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Gln depletion is noticeable by marked reductions of Gln in muscle, immunologic tissues, and (in many cases) blood, with consequences such as reduced protein synthesis, muscle loss, and physical fatigue [ 40, 45, 46].
The exposure of cells to P-specific siRNAs also led to inhibition of virus replication as evidenced by marked reduction in the progeny virion titers.
These changes were accompanied by marked reductions in expression of Sox9 and collagen type 10 mRNA levels.
Our data is also consistent with an interaction between PRR14 and lamin A/C as evidenced by the observation that Prr14 depletion resulted in marked reduction of lamin A/C abundance in C2C12 cells.
UF-CBCT imaging protocol 2 used a marked reduction of iodine volume compared to [ 14] by 53%, 65%, and 72% and [ 19] by 51.5%.
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by marked reductions of
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