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Thus, cardiac stem cell differentiation is characterized by marked activation of the AMP-AMPK signaling cascade manifested by increased AMP/ATP ratio, expression of AMPKα2, and redistribution of p-AMPKα(Thr172) into the nucleus.
CKD is characterized by marked activation of the sympathetic nervous system, as evidenced by increased levels of circulating norepinephrine and an elevated number of sympathetic neural bursts recorded in the peroneal nerve via microneurography [ 2, 21].
Ultimately, prolonged exposure of HAND1-expressing DLD1 cells to Dox for over 2 weeks led to massive apoptosis upon detachment from matrix, as indicated by marked activation of caspase-3.
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This debilitating condition is associated with a marked activation of NFκB activity.
High level of inhibition of Myc cell growth produced by PTX was consistent with the marked activation of apoptosis induced by the drug.
The experiments revealed a marked activation of PMN by the supernatants, i.e. the cells acquired an activated cell shape, released IL-8, their spontaneous apoptosis was delayed and their phagocytic activity was enhanced.
Portal hypertensive gastropathy induced a marked activation of NF-κB, accompanied by a decrease in IκB protein levels and a significant induction of nitric oxide synthase (iNOS) protein.
One interesting finding from our microarray analysis was the marked activation of stress kinase pathways induced by Tax.
SCW immunization induced a marked activation of peritoneal macrophages as demonstrated by a strong spontaneous secretion of TNF compared with rats receiving only PBS or apoptotic cells.
A marked activation of the PbO2+CoOx electrodes, during ca. 3 days of continuous oxygen evolution, is explained as the result of an increase of the Co surface concentration, as shown by XPS and impedance data.
We recently reported marked activation of the Nrf2 pathway in fibroblasts exhibiting an ATPase6 mutation responsible for mitochondrial superoxide overproduction by the respiratory chain [24].
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