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Pore-forming proteins are employed by many pathogens to achieve successful host colonization.
From a clinical perspective, topical immunotherapy of mucosal surfaces with monoclonal antibodies can block entry and transmission of bacteria, viruses, fungi and parasites that infect humans, and defeat some key strategies, evolved by many pathogens, to evade the host immune system.
Post-translational modifications of histones can regulate the extent of condensation and heterochromatin-mediated regulation is one mechanism used by many pathogens to control differential expression of members of subtelomeric gene families [6].
This finding further enhances the notion that targeting transcriptional processes is a key strategy used by many pathogens to evade the host immune response.
Mn2+-dependent superoxide dismutase is encoded by many pathogens to defend against superoxide, while an estimated 4 8% of all proteins encoded in the genome of bacteria are Zn2+-binding proteins.
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Modulation of the host cytoskeleton by bacterial virulence factors is a common microbial strategy used by many pathogens at different stages of the infection process (reviewed in [ 48].
It has been demonstrated that autophagy is also activated by many pathogens and contributes to host defenses confronting microbial infection.
A mechanism of complement evasion employed by many pathogens is binding of complement inhibitors, including factor H FHH), a key downregulator of the alternative pathway.
Bio-agents can induce resistance against various diseases caused by many pathogens such as viruses (Maurhofer et al. 1994), bacteria (Park and Kloepper 2000) and fungi (Bokhari and Perveen 2012).
The model presented combines pathogen transmission, mutation and selection under minimal assumptions that are verified by many pathogens.
Innate immune responses are initiated as a result of recognition by pattern recognition receptors (PRRs) of conserved molecules expressed by many pathogens (pathogen-associated molecular patterns or PAMPs).
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