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IL-10 signaling in T cells is critical for dampening the pathogenesis of collagen-induced arthritis by maintaining the function of Tregs and the recruitment of IL-17+γδ T cells.
Nowadays, the chance to have recourse to immunosuppressants such as mycophenolate and mTOR inhibitors has allowed a large number of kidney-transplanted patients who develop a tumor to recover by maintaining the function of the transplanted organ.
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The differential regulation of DNAJC12 may also reflect general transcriptional changes by maintaining the molecular function of estrogen receptors together with HSP70 [ 77].
The strong conservation of their non-imprinted paralogs suggests that these genes may have compensated for the divergence by maintaining the original functions of the ancestral genes.
In rodents, prolactin is an essential luteotrophic agent by maintaining the corpus luteum function and progesterone production during early pregnancy or pseudopregnancy (40).
In these organisms, they play multiple and critical roles in photosynthesis, by maintaining the structure and function of photosynthetic complexes, contributing to light harvesting, quenching chlorophyll triplet states, scavenging reactive oxygen species, and dissipating excess energy [ 57, 58].
VCAM1 (vascular cell adhesion molecule 1) mediates leukocyte-endothelial cell adhesion and signal transduction, and is critical for adult neurogenesis by maintaining the structure and function of the adult forebrain subventricular zone where neuronal stem cells give rise to neurons [ 38].
These models are kept at a very general level, by maintaining the growth and calcification functions in a generic form, i.e. independent on the exact shape of these functions and on parameter values.
The results showed that elongated morphology (Group C) could help in vitro passaged tenocytes to retain their phenotype and function by maintaining the expression of tenomodulin (tenocyte marker) and collagen I (functional molecule).
While in the absence of frataxin, the interaction between ISCU and NFS1/ISD11 is unstable and very dynamic [19], frataxin might function by maintaining the ISCU/NFS1/ISD11 interaction.
We demonstrate that spirulina, a blue-green algae, was able to negate the deleterious effects of LPS induced inflammation on NPC function, by maintaining the proliferative ability of the NPCs in the face of an acute inflammatory insult.
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