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By maintaining appropriate levels of both Smad4 and β-catenin, HIF-2 α modulates the Wnt signaling pathway during mPanIN progression, with the oncogenic protein Ras expressed in the pancreas.
CHD7 is a member of the SNF2H-like chromatin-remodelling family and has been shown to function as a 'transcriptional rheostat' by maintaining appropriate levels of developmental gene expression (Schnetz et al., 2010).
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Our new guidelines are meant to bring greater competition and transparency to the lender placed insurance market while maintaining appropriate levels of insurance coverage".
Beehive employs several mechanisms and protocols to find and maintain appropriate levels of replication for its objects.
This suggests that STIL maintains appropriate levels of PLK4 via stimulation of its kinase activity.
By being subjected to a reduction rather than a total loss of GDF5 the brachypodism heterozygote mimics the effect of rs143383 in human OA and emphasises the need to maintain appropriate levels of GDF5 to ensure healthy joint function.
The importance of maintaining appropriate MYC levels for cellular homeostasis is underscored by the finding that the MYC gene is frequently over-expressed in numerous cancers including up to 80% of colon carcinomas [5], [6].
This regulatory loop is crucial for maintaining appropriate dMyc levels and normal development.
The most frequent emerging strategies included maintaining appropriate staffing levels and ensuring existing positions were recruited to and filled.
This objective can be attained by maintaining an appropriate level of personal cleanliness and following guidelines for personal hygiene.
Proteolytic mechanisms driven by proteases maintain appropriate protein levels and recognize and degrade the misfolded or mislocalized ones.
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