Sentence examples for by lowering the expression from inspiring English sources
However, the study at Pennsylvania State discovered that the compound can trigger a process in the mitochondria, causing cell death, furthering reducing the defensive capabilities of the cancer cell by lowering the expression of anti-oxidant genes.
Our data suggest that high levels of EndoG may be achieved by lowering the expression of CHIP in cancer cells.
Interestingly, the aged heart is unable to self-repair but PGE2 can restore this lost ability, possibly by lowering the expression of the aging marker gene, TGF-β1.
Recently, UCA1 was found to promote breast cancer cell growth by lowering the expression of the tumor suppressor and cdki p27.
Additionally, miR-519 could further repress tumor growth by lowering the expression of other genes, such as ABCG2 or HIF-1α [ 46, 47].
Hepatitis B virus X protein induces CREB-mediated HULC expression, which subsequently promotes hepatoma cell proliferation by lowering the expression of the cdki p18 [ 152, 153].
Mechanistically, oxaliplatin promotes over-excitability by drastically lowering the expression of distinct potassium channels (TREK1, TRAAK) and by increasing the expression of pro-excitatory channels such as the hyperpolarization-activated channels (HCNs).
Therefore, the estrogen receptor may mediate the hypomethylation effect by either lowering the expression of a factor needed for methylation or inducing the expression of a de-methylating factor.
Furthermore, we demonstrate that PSLs, internalized by splenic macrophages, significantly reduce clinical signs in an experimental MS animal model by suppressing autoaggressive T cells, lowering the expression of inflammatory mediators and inhibiting infiltration of immune cells into the CNS.
This neuroprotection was accompanied by reduced inflammation, with 3,6′-DT lowering the expression of interleukin (IL -1Beta and IL -1Beta nitric oxide synthand, reducinducibleated microglia/macrophages, astrocyte, anitrictroxide numbersynthaseecreducingthe expression of intercellulactivatedon microglia/macrophageshin ischemic brastrocytee [ 112].
The qPCR results illustrate that CUR exerted an anti-inflammatory effect by lowering the LPS-induced expression of iNOS, TNF-α, IL-6, and COX-2.
