In our mouse model, P465L dominant-negative mutation in PPARγ reduced adiponectin expression in the heart and adipose tissue (indicated by lower serum level) which may be contributory to the increased level of cardiac fibrosis under hypertensive conditions.
OPB-9195 prevented the progression of diabetic glomerular sclerosis in OLETF rats mainly by lowering serum levels of AGEs and attenuating AGE deposition in the glomeruli (Nakamura et al. 1997), most probably by scavenging dicarbonyl intermediates (Miyata et al. 1999).
This is also reflected by significantly higher serum levels of leptin and lower serum levels of adiponectin in ZDF rats.
LA is a polyunsaturated fatty acid that has been shown to lower serum levels of LDL cholesterol.
Clodronate treated swine also had significantly lower serum levels of tumor necrosis factor-alpha, interleukin-6, and thrombin.
Lower serum levels of 25(OH D have also been associated with higher BMI and lower physical activity [ 22], which was confirmed by our study.
Patients who did not survive were older and had more severe illness compared to their event-free counterparts as indicated by lower serum albumin levels and impaired left ventricular systolic function, a higher frequency of diabetes as well as higher prevalence of comorbidities such as coronary and peripheral artery disease at baseline when compared to survivors.
Treatment with raloxifene significantly decreased cartilage destruction, as indicated by lower serum COMP levels, compared to vehicle treated mice.
At the early phase (i.e., 0 6 h after reperfusion), chloroquine treatment ameliorated liver I/R injury, as indicated by lower serum aminotransferase levels, lower hepatic inflammatory cytokines and fewer histopathologic changes.
Also, most of the patients were classified as having a relatively mild hyperparathyroidism, which is usually accompanied by lower serum calcium and PTH levels, unlike other reports were hyperparathyroidism was detected in more advanced stages.
