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Therefore, the photoreceptor cell appears to tolerate some degree of rhodopsin mislocalization by low level expression of these trafficking mutants.
A comparison of EDNRB in four cutaneous melanoma cell lines originating from metastases, with three cell lines from primary tumours has shown the metastatic tumours to be characterised by low level expression of EDNRB (Kikuchi et al, 1996).
In Drosophila loss-of-function mutations in the LKB1 gene caused defects in polarity of the oocyte, and this was rescued by low level expression in the germ line of wild-type LKB1, but not by mutation of the residue homologous with Ser (Ser) [ 29].
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The heterologous expression of streptococcal genes in common Gram-negative hosts may be complicated by low-level expression, toxicity to the host, formation of inclusion bodies, and mislocalization of the encoded proteins.
The severe vacuolization of epithelial cells in the thymic cortex was largely reversed by low-level expression of S1PL in the humanized mice, but the thymus of these mice still registered a 60% reduction in thymic cellularity.
In this model, a pNEB induction field is formed, which is defined by low-level expression of Ascl1, Dll1 and Notch receptors.
In the context of suppressive ART, CD8+CD38−/HLA-DR+ cells may be maintained by low-level expression of HIV or, other persistent pathogens, including microbial translocation from the gut.
Drosophila loss-of-function mutations in the Lkb1 gene caused defects in the polarity of the oocyte, and this was rescued by low-level expression in the germ line of wild-type LKB1, but not by mutation of the residue homologous with Ser (Ser) [ 29].
We found that ectopic expression of miR-26b in U251 and C6 glioma cells resulted in diminished proliferation, migration and invasion activity, accompanied by a low level expression of EhpA2.
Since HHFs express detectable levels of endogenous MARCH-VIII and MARCH-IV (Fig. 7A), we wondered whether the steady state level of CD44 or CD81 was affected by the constitutive, albeit low level expression of these ubiquitin ligases.
See inset in Additional File 2 for relative numbers of genes exhibiting high, medium, and low level expression by each method.
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