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However, their usefulness in the mammalian cell is limited by low expression and rapid degradation.
Previous attempts for recombinant expression have been hampered by low expression and solubility of protein fragments.
DeSeq appears to be most stringent in the determination of DE genes, which might be due to the fact that several transcripts are characterized by low expression and elevated biological variation between biological replicates.
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Candidate vaccines to date have been hindered by low expression levels and the induction of non-neutralising antibodies.
The benefits of plants for the production of biopharmaceutical proteins include the ease of scale-up and the low pathogen burden, but the purification of target proteins is often affected by low expression levels and the abundance of host cell proteins in leaf extracts.
The profile of cluster 7, including miR-196a/b and miR-203, showed an inverse pattern to cluster 4, with high expression in early development and gestation followed by low expression in lactation and involution stages.
CD4+ and CD8+ memory cells were defined by low expression of CD25 and high expression of CD44.
However, the immature DCs are characterized by low T-cell activation potential accompanied by low expression of MHCII and costimulatory molecules.
In addition, approximately one-quarter of human breast samples examined contained an additional population that had a distinct luminal progenitor phenotype, characterised by low expression of ERBB3 and low proliferative potential.
This observation also is supported by low expression of Plin1 and relatively higher expression of Plin2 in bone marrow adipocytes (14-month-old), as Plin2 is expressed early in adipocyte differentiation [ 30].
These tumours are characterized by low expression of claudin 4 and 7 and high levels of stem cell markers (CD44high/CD24low) (Hennessy et al, 2009).
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CEO of Professional Science Editing for Scientists @ prosciediting.com