Sentence examples for by looping and binding from inspiring English sources

The LWS-LCR is hypothesized to enhance LWS expression in eutherian mammals by looping and binding to the LWS proximal promoter [ 57- 59].

Mterf1 is a transcriptional termination factor that blocks the heavy-strand mtDNA polycistronic transcription by looping mtDNA across two binding sites: the heavy-strand promoter 2, HSP2, and a termination site within the tRNALeu UUR) gene, adjacent to the gene encoding 16S rRNA (35).

Mutation of the loop and binding of the loop by FVM09 enhance ADI-15946 neutralization by ~10- and 15-fold, respectively.

It is known that HNRNP I represses exon splicing by looping out exons between its binding motifs, which has been found in various kinds of tissues (reviewed in [ 31- 34]).

It is characterized by a 7-strands parallel β-sheet and eight α-helices, connected by loops and turns, forming the NADH binding site.

The WCC acts as the positive arm in the oscillator loop by binding the frq promoter and activating frq transcription (Froehlich et al. 2002, 2003).

Thus, the blockade of the hPD-1/hPD-L1 interaction by pembrolizumab occurs predominantly by binding to the C'D loop and overlaps binding to the C and C' strands to compete with the binding of hPD-L1.

Adjacent, conserved His760 and His761 on α30, further stabilize the RNA loop conformation by binding the U8 phosphate and by stacking onto the G9 and G5 ribose moieties, respectively.

4EBP1 has recently been implicated in a positive feedback loop by binding and stabilising mTORC1, thereby promoting its activation [ 12].

In future work such differences might be incorporated into our model either by adjusting the looping probabilities locally or by distributing specific binding sites along the chromosomes.

The basic helix-loop-helix (bHLH) family of transcription factors is categorized into distinct classes on the basis of biochemical and functional criteria and each member protein contains an HLH domain composed of two amphipathic helixes separated by a loop and a basic DNA-binding domain (1– 3).