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The selected model was then refined by loop modeling and side chain refinement to increase the Profile3D score and to make the model reliable [ 28].
To increase the compatibility score of each residue, the target models were further refined by loop modeling and side chain refinement using DS3.5 ab-initio loop prediction algorithm Looper [ 73] and ChiRotor [ 74] for refining protein side-chain conformations.
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For each of the non-redundant sequences, we annotate the SCOP domain classification and predict structures of missing regions by loop modelling.
The effect was characterized by measuring biochemical properties and by testing of invasion in a chicken loop model and by challenge of six-day-old chickens.
A recent review by Damiano and colleagues compares three closed-loop models and indicates strengths and weaknesses [ 76].
The target model was later refined by side chain refinement and loop modeling to increase the communion score of each residue.
Clearly, these un-protein-like features were still being created by Rosetta's loop modeling method, since there are many CASP7 Rosetta decoys with poke costs higher than those of the corresponding solved structures.
Combined with the observation that the time to the peak response depends on the relative gain of the system, a result predicted by closed loop models, we can be fairly confident the monkeys use a closed-loop strategy.
In order to explore FEATURE's utility in loop modeling, loop conformations were generated by two methods: seed sampling and deformation sampling [ 54].
Structures of missing regions with less than 7 residues in PDB chains are predicted by high-quality loop modelling using MODELLER [ 9], to help structure prediction and function analysis.
By contrast, the outer loop model primarily determines the scope and sequence of items or knowledge units to be learned.
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