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Treatment is by local application of corticosteroids, which greatly diminish lymphocyte infiltration, and by avoidance of further contact with the sensitizing agent.
It has been shown that the mitogen-activated protein kinase (MAPK) system can be activated by local application of CFA [7 9].
For instance, to obtain an SD wave segment in submerged chicken retina (for details, see Ref. [20]), an initially closed circular SD wave front can be broken (at a diameter of about 0.75 mm) by local application of 0.5 ml Ringer solution through a pipette (tip diameter 0.5 mm) containing a tenfold raised Mg2+ concentration (10 mM) (Fig. 4).
Some researchers are already trying to establish new treatments to accelerate the regeneration of periodontal tissue by local application of human recombinant cytokines to stimulate proliferation and differentiation into hard-tissue forming cells of undifferentiated mesenchymal cells among periodontal ligament cells.
In one patient, a herpes labialis infection occurred and was controlled by local application of aciclovir.
radiatum of CA1 region by local application of NMDA (NMDA 500 μM plus NaCl 1 M).
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Inward currents were elicited by local applications of GABA at a holding potential of −90 mV in control conditions and in the presence of MNI-glutamate.
Consistent with this interpretation, the inhibition of PDGFRβ signalling in Sesn2 KO mice by imatinib significantly exacerbated the pulmonary lesions induced by the local application of elastase.
Indeed, nerve conduction can be blocked by the local application of cold to a nerve fibre.
Axonal elongation is induced by the local application of actin depolymerizing reagents to neurite tips, suggesting that factor Y regulates axon specification via actin depolymerization [1].
By contrast, local application of GABA or glycine leads to a decrease in transmitted light intensity [35] which might account for the observation that the largest decrease in light transmission occurred in the dorsal horn where GABAergic synaptic interactions are prominent [44].
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