Based on the model version of optimized parameters, gained in the simultaneous model fit, the effect of inter-individual variability of CYP3A4 and UGT1A3 protein expression levels was investigated by linking the protein expression data of 150 liver samples via the described relative abundance approach in equation (11), using individual 1 as reference.
By linking the gene expression changes to these biological outcomes we aim to strengthen the process of identifying target genes involved in the cellular response to BaP exposure.
By linking the current mathematical expression with the existing multiscale model of calcium and bone homeostasis, a single ordinary differential equation construct using CTx and BSAP was capable of describing observed longitudinal changes in LSBMD during and after discontinuation of denosumab treatment.
Logistic regression was used to model eve expression by linking the regulator concentrations as continuous input variables, to eve's expression state as the binary output.
By linking the level of microRNAs to the expression of predicted target mRNAs across 19 single cells that are phenotypically identical, we observe that the predicted targets are significantly anti-correlated with the variation of abundantly expressed microRNAs.
By linking the drug activity to the gene-expression profiles in cancer cell lines, the Sanger GDS dataset has facilitated the identification of several genomic markers of drug sensitivity in cancer cells [ 33].
This latter has a key role for receptor expression and signal transduction, by linking the antigen-binding Ig chains to intracellular tyrosine kinases of the Src-family.
The database allows for the correlation of expression levels and function by linking the EST data with the microarray results, since many of the ESTs were printed on the microarray slides.
These values [ 42- 46] were incorporated into the model through coupling constraints [ 36, 47], which account for turnover rates by linking gene expression to metabolism through the dependence of reaction fluxes on enzyme concentration [ 35].
The model was further improved by linking and expression as a single chain for more efficient structure determination studies, as well as incorporation into a membrane.
