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PBSA and TBSA hydrogels loaded with atRA demonstrate a small initial burst release of atRA followed by linear release over 10 days in PBS at 37 °C.
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BMP-2 release from PLGA microparticles resulted in a moderate burst release followed by minimal cumulative release, while BMP-2 release from gelatin microparticles exhibited minimal burst release followed by linear release kinetics in vitro.
All matrices showed lag time of approximately 2 h followed by linear release.
IL-1ra release kinetics were characterized by an initial burst release reducing to a linear release over the first 10 days.
The CrmA release kinetics were characterized by an initial burst release, which was reduced to a linear release over ten days.
Inspection of these data reveals ∼15% of the loaded peptide to be released over the first several days of incubation, followed by the linear release of an additional ∼40% over the remainder of the 240-day experiment.
Furthermore, the GO/PPy nanocomposite film exhibits a linear release profile that persists over several hundred stimulations, indicating that the release platform could be used for long-term drug-release applications that require repeated dosing over time.
These surfaces also showed a small burst release (ca. 5%) and a linear release behaviour (R2 = 0.998) over the following 19-h period.
The HY was released in a multiphasic fashion including an initial burst release, followed by two separate periods of linear release.
In response to voltage stimulation, the nanocomposite releases drug with a linear release profile and a dosage that can be adjusted by altering the magnitude of stimulation.
Release was observed over approximately ten days, with varying release profiles, including burst as well as linear release.
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