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Such trends will need to be confirmed by large scale prospective observational studies which will also assess the putative accelerating effect of HIV-related neurocognitive impairment on other types of prevalent dementia and neurodegeneration.
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We are aware of the small cohort of patients in this study, which limits the power of multivariate analyses and thus warrant validation and refinement by larger scale prospective trials.
Third, our study results, if further confirmed by large-scale prospective studies, provided a useful marker to stratify the patients.
The results of this study need to be confirmed by large-scale prospective randomized studies.
If further confirmed by large-scale prospective studies, these findings have great potential clinically.
To overcome these problems, validation by large-scale prospective studies should be performed in the future.
Our results should be confirmed by a large scale, prospective, randomized clinical trial.
In addition, corticosteroids use should not be regarded as routine pharmacologic therapy, although this may need confirmation by further large scale prospective study.
Our meta-analysis reinforces earlier results by including several recently published large scale prospective cohort studies.
A large scale prospective study will be needed to confirm our current findings.
Further large scale prospective studies are needed to confirm this relationship between wound infection and time of repair.
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