This large-scale modification of functional circuits in the brain by a single transcription factor in a single stem cell is unprecedented and reveals a surprising capacity for novel neural circuit formation in the developing brain, which may provide a paradigm for large-scale evolutionary modification of brain connectivity.
PACIFIC GROVE, CALIFORNIA An international group of scientists, ethicists, and governance experts meeting here this week has agreed that research into large-scale modification of the planet is "indispensable" given the "threats" posed by climate change.
The switch from maternal to zygotic developmental programs is associated with large-scale modification of chromosomes.
These initial results require validation by larger scale studies.
" Gene drive developers are in effect saying "Give me a gene drive and an organism to put it in and I can wipe out species, alter ecosystems and cause large-scale modifications".
If the Apollo I disaster experience of 17 years ago provides a model, large-scale modifications will be required and even a total redesign of the shuttle could become necessary.
In the case of RNA splicing, use of reporter genes can be unusually problematic as splicing is influenced or regulated by large-scale processes like chromatin modification [1], [2], [3], [4], [5], transcription [6], [7],, and mRNA export [13], [14].
Yet all are (potentially) amplified by large-scale regional or global environmental change, involving a complex mix of social and environmental modifications resulting from human activities largely associated with globalization [ 74].
Enzyme-mediated modification sites on numerous substrates could be revealed by large-scale proteomic analysis of enriched peptides.
Presently, both topical chemical application and genetic modification are widely used pest management practices, especially by large-scale agricultural efforts.
