Sentence examples for by large scale comparative from inspiring English sources
Rapidly evolving lineage specific gene families are intrinsically difficult to analyze by large scale comparative genomic analysis [ 35].
There were many pioneering works on the molecular evolution of mammalian protein sequences [ 4], which were followed by large scale comparative analyses between species.
By large-scale comparative analyses using structural alignment and hidden Markov model methods, it was found that the majority of SSPs have evolved via the DSF mechanism, and a much smaller fraction, via CP.
This approach is often taken by large-scale comparative genomics analysis such as MIPS, OMA or RoundUp [ 2- 4], which analyze the sequences pairwise due to computational constraints.
It is already on the way, as evidenced by large-scale comparative transcriptome projects (for example [ 16]) and the growing number of genome sequencing projects focused on phylogenetically key species.
The same conclusion was reached by several large scale comparative studies, based on transcriptomic or proteomic analyses, which lead to the identification of biological processes and genetic determinants affecting rice grain properties.
In principle, without knowing anything a priori about the rate of gene conversion, finding homogenized repeats in the general population might require a large scale comparative sequencing effort that would be complicated by the repeated nature of the template.
Within the framework of this study we established the first large scale comparative proteomics analysis for Plasmodium falciparum.
Large scale comparative evaluations of training in PBS are lacking.
