In all 3 groups, the profiles of SI were characterized by large scale alteration of EGF, platelet-derived growth factor (PDGF) and NGF/neurotrophin signaling.
These changes may be further followed by large-scale alterations in genomic DNA [ 19].
In addition, we demonstrated that the abundance of the vast majority of histone species do not significantly change in primary tumor samples and cell model systems suggesting that at least some malignancies are not accompanied by large-scale alterations in the global histone proteome.
Intensively managed row crop agriculture has fundamentally changed Earth surface processes within the Mississippi River basin through large-scale alterations of land cover, hydrology and reactive nitrogen availability.
For large-scale alterations, the CGH data were averaged for sliding windows of 130 kb over the relevant chromosomes.
We further hypothesize the presence of a larger scale alteration around this period, which is beyond all phenomena described.
Plant growth and crop productivity is largely limited by environmental factors that include water-deficit stress, such as by salinity, which bring about large-scale alterations in gene expression in plants [ 7]. High NaCl concentrations in soil cause salinity stress and limit the geographical distribution of most highly salinity-sensitive plants, including legumes [ 8, 9].
Genome-wide copy number and genotype analysis of 10 cervical cancer cell lines by array CGH and SNP array showed highly complex large-scale alterations.
Breast cancer not only is driven by somatic point mutations and epigenetic alterations but also characterised by extensive copy number changes [ 8, 9], and these large-scale alterations are likely to be informative of its biology in addition to clinico-histopathological features and expression profiles.
