Sentence examples for by large scale alteration from inspiring English sources

In all 3 groups, the profiles of SI were characterized by large scale alteration of EGF, platelet-derived growth factor (PDGF) and NGF/neurotrophin signaling.

These changes may be further followed by large-scale alterations in genomic DNA [ 19].

In addition, we demonstrated that the abundance of the vast majority of histone species do not significantly change in primary tumor samples and cell model systems suggesting that at least some malignancies are not accompanied by large-scale alterations in the global histone proteome.

Only in 5WexGF intestines, both SI and LI, large scale alteration of chemokine signaling was observed.

This suggests an extensive and large scale alteration of the metabolic system in the SPF small intestine.

We further hypothesize the presence of a larger scale alteration around this period, which is beyond all phenomena described.

"These changes, combined with increased ice-free land areas from glacier retreat, will drive large-scale alteration to the biological functioning, appearance, and landscape of the [Antarctic peninsula] over the rest of the 21st century and beyond," they wrote.

Large-scale alteration of gene expression in psoriasis plaques is driven, in part, by differences in the composition and abundance of cell types present within lesional and non-lesional skin [ 6, 12].

In western Pacific islands, this is partly causal of the ongoing large-scale alteration of coastal zones to aquaculture.

Plant growth and crop productivity is largely limited by environmental factors that include water-deficit stress, such as by salinity, which bring about large-scale alterations in gene expression in plants [ 7]. High NaCl concentrations in soil cause salinity stress and limit the geographical distribution of most highly salinity-sensitive plants, including legumes [ 8, 9].

These initial results require validation by larger scale studies.