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Some of this type of error can be mitigated by large sample sizes, but some systematic errors cannot.
They involved non-calibrated examiners, but this was partially compensated by the fact that dental caries detection threshold was a cavitated lesion, and by large sample sizes.
It is important to stress that the statistical significance seen in the comparisons we report are driven by large sample sizes, not large effect sizes.
As a complementary approach, we also assessed the genomic distribution of genes classified as sex-biased using the classic fold-change threshold of 2, which is less likely to be influenced by large sample sizes.
Furthermore, because of the statistical power provided by large sample sizes, population studies using global databases could potentially replace individual prospective studies as a means of validating new biomarkers, saving both time and money [ 38, 51].
However, we should stress that the statistical significance seen in the comparisons are driven by large sample sizes, not large effect sizes and as in the ISC study, the proportion of variance currently explained is negligible (<1% of the variance).
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But this might be made up for by large sample size to some extent.
The residue variants identified in this study needed to be further verified by large sample size with more even geographic distributions, and combined with biological functional studies in both neuron cell and animal models.
Because the goodness-of-fit chi-square is inflated by large sample size [ 66], we also examined differences in CFI across nested models, with difference in the CFI (ΔCFI) ≤.01 considered evidence of measurement invariance [ 67].
However, for very large data sets that are characterized by large sample size, it can be difficult to fit REM using commonly available statistical software such as SAS since they require inordinate amounts of computer time and memory allocations beyond what are available preventing model convergence.
The type I error rates of PCA were not significantly inflated by larger sample sizes (Figure 2).
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