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This technique has been previously limited by large sample requirements.
Although thermal stability assays offer advantages over other approaches such as IC50 measurements, CD-based stability measurements are hindered by large sample requirements and low throughput.
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Despite of increasing public awareness, the development of PROMs using traditional psychometric methodologies often is lengthy and constrained by the large sample size requirement, resulting in substantially increased costs and resources.
The functional effect of these SNPs was addressed neither by association study due to large sample size requirements nor by gene expression analysis due to unavailability of minor allele homozygotes.
As a result, there are not particularly large sample size requirements.
By definition, cross-sectional surveys are not conducted on a recurrent basis because of the large sample size requirements.
Disadvantages of SEMs that have been previously noted include potentially large sample size requirements and potential problems with skewed data.
For these three traits, power analysis revealed large sample size requirements (>1000) to detect invasion status differences.
This imprecision ultimately leads to larger sample size requirements for clinical trials.
Samples for T were assayed in duplicate DSL-40000), whereasampleses for E2 were determined in singleton (DS-43100), owing to the larger sample volume requirement of that assay.
This was necessitated by the very different sample requirements of each method.
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