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It was previously found 100% of LOH (loss of the wild-type allele) in childhood adrenocortical cancer with the R337H germ-line mutation [9], [10], which is consistent with the classical two-hit mechanism of cancer proposed by Knudson [19].
The technique of asymbiotic seed germination by in vitro culture was first introduced by Knudson (1922).
All patients underwent standard spirometry according to ATS guidelines [ 19], using the reference values derived by Knudson [ 20].
The two-hit process postulated by Knudson (Knudson, 1971) falls within this class of lineage selection effects.
Concepts delineated by Knudson regarding hereditary cancers in man and experimental animals will probably be found operative in certain demographic units (oncozoons) among feral fishes bearing neoplasms.
Percent predicted forced expiratory volume in 1 s (%FEV1) and percent predicted forced vital capacity (%FVC) were calculated using the method reported by Knudson et al. (15).
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This installment of the free series, devoted to new work and new choreographers, features dances by Elise Knudson, Maxine Steinman, Raymundo Costa and Ellis Wood.
In 2007, a descriptive study by Park and Knudson report that people with medically unexplained physical symptoms (MUPS) were more likely than those without MUPS to rate their mental health as fair or poor [ 43].
The term 'hepatopulmonary syndrome', the triad of liver disease, an increased alveolar-arterial gradient while breathing room air, and evidence of intrapulmonary vascular dilatations, was coined in 1977 by Kennedy and Knudson [ 2].
(Dunning) FLY-BY-NIGHT DANCE THEATER (Tomorrow) Aerial dance by Julie Ludwig, with guest choreography by Jody Oberfelder, Elise Knudson and Elie Venezky.
Allelic loss, manifested as loss of heterozygosity (LOH) at polymorphic loci, is recognised as a hallmark of tumour suppressor genes, whose other allele is inactivated by point mutations or by some other mechanism (Knudson, 1985).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com