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The yeast data consists of expression changes caused by knockout of each of the 173 genes.
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It was found that the inactivation of ODHC by knockout of the kgd gene enhanced L-ornithine production.
Pigs engineered by knockout of sialoadhesin were still susceptible to infection, while CD163 knockout resulted in pigs that were resistant to infection.
SN29428 activation under hypoxia was strongly attenuated by the pan-flavoprotein inhibitor diphenyliodonium, but less so by knockout of POR suggesting other flavoreductases contribute.
In addition, lactate and acetate synthesis were blocked by knockout of ldh (encoding lactate dehydrogenase) and pta (encoding phosphotransacetylase), leading to a 44.9% increase in GlcNAc production (from 2.45 g/L to 3.55 g/L) in shake flasks.
By knockout of rpoS in Pseudomonas aeruginosa PAO1, the biofilm formation on the electrode was enhanced and the bacterial cells were adapted to a new electron shuttle, which promoted the extracellular electron transfer and improved the performance of BES.
The reason for this assumption was that the knockout of reaction PFL caused a much higher flux-sum value of NADH than that caused by knockout of reaction LDH-D, although knockout of reaction LDH-D resulted in a slightly enhanced flux-sum value of NADH as well.
Even by knockout of a single VEGF-A allele mice were unable to survive [5] [7].
We have found that Swe1 is SUMOylated on K594 and that this SUMOylation is prevented by inhibition of Cdk1-Clb activity or by knockout of SIZ1.
In these experiments, the induction of rapid internalization of PC, characteristic of the scramblase activity, was unaffected by knockout of the ABCA1 gene.
However, in order to rule out any potential artifacts specific to this strain combination, we introduced the Factor VIII KO mutation into a different SCID mouse, namely, SCID induced by knockout of the RAG gene.
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