Sentence examples for by knocking down expression from inspiring English sources

Viability of the human HeLa cell line, was also unaffected by knocking down expression of Rpn13 [15] or Uch37 [16].

It confirms a previous report that showed a similar growth stimulation by knocking down expression of a regulatory subunit of PKA [17].

Moreover, this effect on available ligand could be rescued by knocking down expression of Notch1 with siRNA.

As well as mutant strains, individual gene function may be disrupted by knocking down expression using RNA interference (RNAi).

Another application of siRNA is to sensitize chemotherapy by knocking down expression of multidrug resistant genes in breast cancer cells.

We attempted to test msl-3 as one such candidate by knocking down expression of sim-msl-3 using shmiRs but unfortunately failed to do so.

Therefore, we eliminated the function of FLRT1 and FLRT3 proteins by either knocking down their expression with morpholinos or by knocking down the expression of RND1, the downstream effector of FLRT proteins, as done previously [2].

For another example, in basal-like loss related Bayesian network motif, given the importance of miR-21 in tumorigenesis, Yang et al. found that miR-21 affects the expression of many of its targets through translational inhibition by knocking down the expression of endogenous miR-21 in MCF-7 breast cancer cells [ 32].

We then assessed whether the Axin/TNKS/KIF3A complex affects glucose uptake by knocking down the expression of Axin, TNKS1/2 or KIF3A individually in 3T3-L1 adipocytes by siRNA-expressing adenoviruses.

In contrast, upregulation of FOXO3 protein level by knocking down the expression of βTrCP1 in breast cancer cells suppresses their tumor growth in vivo.

Autophagy was inhibited by knocking down the expression of essential autophagy protein ATG5.