However, in vitro tissue culture studies have shown that Bbx by itself stimulates only weak growth, and that normal growth also requires the action of the steroid molting hormone, ecdysone [2], [3].
At the same time, the investigation is intended to examine whether the scale of production by itself stimulates technological activity and/or it acts as a proxy of other determinants of innovation.
He saw that OnCue would neither make money by itself, nor stimulate sales or margins for its main act, x86 processors.
Ecdysone by itself cannot stimulate normal growth of the imaginal disks in vitro, and it appears that ecdysone acts synergistically with Bbx to promote normal growth in the wing imaginal disks [2], [3].
In female mammals, ovulation is induced by luteinizing hormone (LH) secretion surge from the pituitary gland, an event which is itself stimulated by gonadotropin releasing hormone (GnRH) secretion from neurons in the hypothalamus [ 8].
Myelin production is itself stimulated by axonal activity [Demerens et al., 1996] so abnormal neuronal functional activity may be reflected by changes in myelin patterning [Fields, 2005], something demonstrated post-mortem in adults with autism [Zikopoulos and Barbas, 2010].
In addition, ethanol itself stimulates carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism (Toh et al, 2010).
31 Thus insulin resistance initiated by poor control of glycemic levels, rather than by insulin itself, may stimulate atherosclerosis.
However, WDR5 by itself does not stimulate methyltransferase activity of the MLL1 SET domain in vitro [17], [20], [22].
In addition, by itself it can stimulate TH2 cytokine production [ 40].
