We concluded that this molecule is a bone fide fish ortholog for mammalian Fas by several lines of evidence: its domain structure, similarity of its genomic structure, the conservation of synteny of the Fas gene-containing genomic region between humans and Medaka, a molecular phylogenetical evidence and the functionality of the Medaka Fas death domain for the transmission of apoptotic signals.
Its domain structure is characterized by several Zn2+-finger motifs and a specific SOL-homology (SOH) domain at the CysPc N- and C-termini, respectively.
However, its therapeutic value is limited by its complex domain structure, high cost of production, instability, and poor tissue penetration due to sequestration by heparin sulfate proteoglycans (HSPGs).
Detailed models of the full-length receptor, constrained by its rigid domain structures and its membrane anchoring, explain how the bispecific DARPins connect two membrane-bound HER2 molecules, distorting them such that they cannot form signaling-competent dimers with any EGFR family member, preventing any kinase dimerization, and thus leading to a complete loss of signaling.
The dual function is supported by its multi-domain structure composed of an N-terminal domain (a four α-helix bundle), a central GTPase domain (with a ras-like fold) and the C-terminal M domain (for methionine rich).
In soft magnetic thin films [1 4], their moment distribution and macroscopic properties are strongly affected by the domain structure and the domain structure even determines their practical applications [5, 6].
These enzymes are highly modular and usually classified by their domain structure [3].
The building blocks of TAAs can be viewed in two ways: by their domain structure or by their sequence motifs.
These clades are also supported by protein domain structure, gene expression, and chromosomal location.
Clade 3 includes human PARP7 and PARP9-15, prothats thareare heterogeneous both by their domain structure and function [9,21].
