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A crucial innovation was to exploit dissipative dynamics, which Cowan and Wilson accomplished by introducing a sigmoidal activation function as a canonical saturating response function [58].
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RESULTS Platelet inhibition by ticagrelor was described by a sigmoidal Emax model.
The IC50 values were determined by fitting a sigmoidal dose response curve on GraphPad Prism.
The EC50 was determined by fitting a sigmoidal dose response curve on GraphPad Prism.
The maximal effective concentrations (EC50) were determined by fitting a sigmoidal dose response curve on GraphPad Prism (GraphPad Software).
The half-maximal inhibitory concentration (IC50) values were determined by fitting a sigmoidal dose response curve on GraphPad Prism.
The IC50 was calculated by fitting a sigmoidal dose response curve using Sigma Graph Pad Prism® version 6.0.
The lethal temperature (=LT50, the temperature that results in 50%% mortality) was determined from the mortality curves, derived by fitting a sigmoidal function [(mortality=a/(1+b*exp−kTa)].
Maximum slopes of GFP expression versus time were determined by fitting a sigmoidal curve to the raw data and taking the derivative giving the expression rate.
The concentration-response curves were drawn by fitting a sigmoidal curve to the data points at different drug concentrations using the curve-fitting function of Igor Pro (WaveMetrics).
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