Other models [13,14] work well in predicting nucleosome occupancy in vivo by introducing a position-independent component, PL, to represent sequences that are generally favored or disfavored regardless of their position within the nucleosome (most notably, poly dA dT) tracts, which are strongly disfavored by nucleosomes) [14].
We tested the IS1 peptide in our system and could strongly increase its cleavage potential by introducing a glycine at position 7 to increase flexibility (Table 1).
Similar to the triple variant, the S215H variant did not bind MgADP, suggesting that the perturbations caused by introducing a histidine at position 215 greatly impair the ability of MgADP to bind to TtPFK.
Mercedes could have chosen a safer route by introducing a new brand positioned as "by Mercedes". Although a costly strategy, it would have leveraged the maker image while insulating it from any possible degradation associated with a less prestigious car.
In addition to analyzing the A-loop, we analyzed the C-terminal region by introducing a stop codon at position 609 or 588 (Figure 1C).
For instance, it has been reported that solubility can be improved by introducing a Cysteine at 230 position, which makes a disulfide bond with Cys210 and promotes proper folding of recombinant CA [ 10].
In the present study, we refine and extend the concept of "topohydrophobic" positions, by introducing a generalized topohydrophobic index, which evaluates at each position of a given sequence alignment the fraction of amino acids belonging to the hydrophobic group.
Marcel developed his position by introducing a number of important philosophical distinctions for which he became well known.
This gave the government the chance to weaken the federalist position by introducing a bill for electoral reform.
In contrast, the Schanz osteotomy (Fig. 1) was performed by introducing a valgus, and sometimes extension, position to the distal femoral segment but without the proximal displacement of the Lorenz procedure.
