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The cell morphology and the FtsZ polymerization assays indicated that these compounds inhibited the bacterial proliferation by interfering the function of bacterial FtsZ.
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The CNVs with pattern discordance may make an impact on these diseases by interfering the genes' functions explicitly or through cell-recognition in complicated immune pathway.
IFN α has recently been shown to affect vasculogenesis by interfering the phenotypes and function of EPC [ 64].
The observation that the epididymal plasma factor lowered the intracellular cAMP level of spermatozoa in a concentration-dependent manner suggests that it may block the motility of caprine cauda spermatozoa by interfering the cAMP dependent motility function.
Thus, by interfering the proapoptotic and cell cycle regulatory functions of p53 and TAp73, N-terminus-truncated p73 isoform (∆Np73) acts as an oncogene and it has been reported to be overexpressed in several tumours [ 4].
Such agents exert their effects by inducing changes in those genes or by interfering with the function of the proteins that the genes encode.
Previous studies have demonstrated that viruses have evolved mechanisms to inhibit MHC class I expression by interfering with the function of the MHC class I assembly machinery in the endoplasmic reticulum and by exploiting endoplasmic-reticulum-associated degradation pathways [ 38].
Because fibroblasts and myofibroblasts are now believed to play a critical role in promoting the growth of cancer cells [ 5, 6], we performed this study to determine if butein could suppress the growth of human breast cancer cells co-cultured with fibroblasts by interfering with the function of the fibroblasts.
Surface-associated capsular polysaccharides (CPSs) protect bacteria against phage infection and enhance pathogenicity by interfering with the function of the host innate immune system.
When these proteins bind to a methylated promoter, they recruit HDAC, and the interaction of these two epigenetic events inhibits gene expression by interfering with the function of transcription factors and the compaction of the chromatin structure [ 39- 41].
This reinforces the belief that drug molecules, at least partly, work by interfering with the function of multiple targets within the cellular milieu.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com