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CCN proteins have been suggested as potent angiogenic modulators, with activity mediated by interactions with different integrins and growth factors [ 41].
This suggests that the WASH complex could be recruited by interactions with different adaptors to distinct endosomal tubules or membrane domains [20].
The regulation of high oxidative gene expression by PGC-1 is mediated by interactions with different isoforms of a family of nuclear hormone receptors, the peroxisome proliferator-activated receptors (PPARs) (Gilde and Van Bilsen 2003).
However, relevant Mmp9 activity also depends upon release of the latent form of the enzyme from cellular stores, and is heavily regulated by interactions with different tissue factors [ 33].
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PIMs, lipomannan and lipoarabinomannan all display several immunomodulatory properties by interaction with different receptors of the immune system.
PIMs, lipomannan and Man-LAM all display several immunomodulatory properties by interaction with different receptors of the immune system.
They provide protection against deleterious cellular stress by interaction with different cochaperones and other partner-proteins or by inducing expression of kinases, hormone receptors, transcription factors, or antioncogenic proteins [ 11, 12].
Recent studies on lectins in P. membranacea indicated that the expression of galectin lec-1 was influenced by the presence of the phycobiont [ 84], and the evolution of galectin lec-2 was driven by interaction with different strains of the phycobiont Nostoc[ 85].
This is the first study to demonstrate effects of intrahepatic aromatase mRNA expression by interactions with the different carcinoma cell lines derived from primary tumors of the liver metastasis.
These effects are associated with the special microenvironment surrounding each cell which is established by individual cell-to-cell attachments and intercellular communication processes mediated by diverse interactions with different ECM components and by the release of cytokines or the local exchange of microRNAs and membranous micro vesicles [ 47- 49].
In summary, Dia proteins control diverse fundamental biological processes that are mediated by combinatorial interactions with different binding partners.
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