Surface properties of layered zeolite frameworks, or 2D zeolites, derived from zeolites UTL and ITH are probed by interaction with several small molecules (CH4, CO2, H2O, H2, N2).
The E2F family of transcription factors, by interaction with several partners such as pRb, p107 or p130, are thought to regulate the cell cycle [31], [32] and trigger signals that also either promote cellular growth, cell cycle exit, or terminal differentiation in neurons [32], [33].
p73 activity can also be regulated by interaction with several cellular partners such as Mdm-2, Yap, ASPP family proteins and these are often altered in cancer cells.
Viral binding to DC is mediated by interaction with several surface molecules, e.g. the CD4 receptor, CCR5 and/or CXCR4, C-type lectins such as DC-SIGN, and the macrophage-mannose receptor [ 5].
For NFKB1 transcription, an inhibitory effect was not implemented, since the activity of NF-κB at the protein level is controlled by interaction with several IKB proteins [ 48] which were not included in our ECM network model.
The effects of leptin hormone are mediated by interactions with several physiological regulatory systems and the cytokine network, and by targeting cells directly.
The principle behind this, proposed 30 years ago, is that tissues house stem cells within specific locales and stem cell fate is influenced by interactions with several components of their three-dimensional microenvironment, including soluble and immobilized factors, the extracellular matrix (ECM) and signals presented by neighboring cells.
The membrane trafficking and regulation of Gap1 are mainly governed by interactions with several intracellular factors and by post-translational modifications of its residues exposed to the cytosol.
The Epsilon clasp motif comprises an extended 'wafer' arrangement of four histidines (two contributed from each subunit), which is supported by interactions with several conserved serines from helices 3, 4 and 6.
While lack direct transcriptional activation capacity, these proteins regulate gene expression by changing the conformation of DNA and/or by direct interaction with several transcription factors (reviewed in [45]).
Involvement of Filamin in signal transduction is inferred by its interaction with several components of the NF-κβ pathway and with the small GTPases RhoA, Rac, Cdc42 and RalA, and also with regulators and effectors of small GTPases like Trio, FilGAP, PAK1 and ROCK, and β1 integrin [17] [21].
