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In the chicken domain of alpha globin genes this unstable DNA sequence seems to be partially protected by interaction with nuclear matrix proteins.
Classically, E2 is thought to exert its effects via genomic signaling mediated by interaction with nuclear estrogen receptors.
Although the cellular functions of HIPK1 are not very well defined, available evidence indicates a role in the regulation of apoptosis by interaction with nuclear proteins [ 16, 21].
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Recently, Guelen et al. [ 36] identified ~1300 sharply defined large domains defined by interactions with nuclear lamina components.
Thus, Sp1 activity can be regulated by diverse factors including high glucose and glucosamine, growth factors such as TGF-β and intracellular signaling such as cAMP, PKC and ERK, as well as by interaction with other nuclear factors [14] [17], [52], [54], [55].
The major effects of thyroid hormone are exerted by interaction with its nuclear receptors.
Currently available data suggests that Met may mediate its actions by interaction with other nuclear proteins such as Taiman (see Jindra et al. (2013) Annu Rev Entomol for a comprehensive review).
HBx is a multifunctional protein, which does not bind directly to DNA, but exerts transcriptional activation by its interaction with nuclear transcription factors and modulation of cytoplasmic signal transduction pathways, such as RAS/RAF/MAP signalling (Ng and Lee, 2011).
While its role in the reverse transcription process implies interaction with the nuclear form of the DNA repair enzyme UNG2 for modulation of the virus mutation rate [4] [6], it was suggested that Vpr participates in the DNA nuclear import process through docking to the nuclear envelope (NE) by interaction with components of the nuclear pore complex [7] [10], such as the nucleoporin hCG1.
The information is unfortunately degraded by interactions with the nuclear spins of the atoms that make up the surrounding lattice.
These pleiotropic activities are regulated by interaction with the vitamin D nuclear receptor (VDR) (Holick, 2003; Bikle, 2010).
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