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These subtleties could potentially bare important information, as they might be indicative of different biological functions, e.g., by interaction with different cellular components.
PIMs, lipomannan and lipoarabinomannan all display several immunomodulatory properties by interaction with different receptors of the immune system.
PIMs, lipomannan and Man-LAM all display several immunomodulatory properties by interaction with different receptors of the immune system.
They provide protection against deleterious cellular stress by interaction with different cochaperones and other partner-proteins or by inducing expression of kinases, hormone receptors, transcription factors, or antioncogenic proteins [ 11, 12].
Recent studies on lectins in P. membranacea indicated that the expression of galectin lec-1 was influenced by the presence of the phycobiont [ 84], and the evolution of galectin lec-2 was driven by interaction with different strains of the phycobiont Nostoc[ 85].
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CCN proteins have been suggested as potent angiogenic modulators, with activity mediated by interactions with different integrins and growth factors [ 41].
This suggests that the WASH complex could be recruited by interactions with different adaptors to distinct endosomal tubules or membrane domains [20].
The regulation of high oxidative gene expression by PGC-1 is mediated by interactions with different isoforms of a family of nuclear hormone receptors, the peroxisome proliferator-activated receptors (PPARs) (Gilde and Van Bilsen 2003).
However, relevant Mmp9 activity also depends upon release of the latent form of the enzyme from cellular stores, and is heavily regulated by interactions with different tissue factors [ 33].
The function of proteins in the cell is almost always mediated by their interaction with different partners, including other proteins, nucleic acids or small organic molecules.
One of the reasons commonly given is that housework is more resistant to automation because it is characterized by constant interaction with different objects of unpredictable shapes; on the contrary, the assembly line in a factory, for instance, consists of repetitive work accomplished with the same type of objects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com